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The Food and Drug Administration (FDA) on Aug. 25 stated that it has suspended approval for a vaccine against chikungunya, a mosquito-borne virus.

Because of reports of serious adverse events following administration of the vaccine, the FDA’s Center for Biologics Evaluation and Research (CBER) “believes [the] vaccine is not safe and that continued administration to the public would pose a danger to health,” the FDA <a href="https://www.fda.gov/safety/medical-product-safety-information/fda-update-safety-ixchiq-chikungunya-vaccine-live-fda-suspends-biologics-license-fda-safety">said</a> in a statement.

France-based Valneva makes the vaccine, known as Ixchiq.

“As we determine potential next steps, and as the clear threat of chikungunya continues to escalate globally, Valneva remains fully committed to maintaining access to our vaccine as a global health tool for addressing and preventing outbreaks of this devastating illness,” Valneva CEO Thomas Lingelbach <a href="https://valneva.com/wp-content/uploads/2025/08/2025_08_25_FDA_IXCHIQ_Update_PR_EN_Final2.pdf">said</a> in a statement.

The FDA originally approved Ixchiq in 2023 to prevent disease caused by the chikungunya virus in adults deemed to have an increased risk of exposure. The Centers for Disease Control and Prevention (CDC) in 2024 recommended the vaccine for people traveling to certain countries.

Health officials <a href="https://www.theepochtimes.com/health/us-advises-older-adults-not-to-receive-chikungunya-vaccine-for-now-5856323">said</a> in an alert in May that they were advising a pause in administering the vaccine to elderly adults because of reports that some of those vaccinated had been experiencing serious adverse events (SAEs), including neurologic and cardiac problems.

This included 38 SAE reports for 32 unique cases (seven U.S. cases, 25 foreign cases), including 21 hospitalizations and three deaths.

After CBER Director Dr. Vinay Prasad <a href="https://www.theepochtimes.com/us/top-fda-vaccine-official-departs-agency-5894223">resigned</a>, the FDA in early August <a href="https://www.theepochtimes.com/health/fda-ends-suspension-of-chikungunya-vaccine-adjusts-label-5898252">ended</a> the recommended suspension, stating that an updated assessment of risks and benefits for Ixchiq showed that the benefits still outweighed the risks for some people.

In the new announcement, regulators said that is no longer the case.

The latest risk-benefit assessment includes four new foreign reports that have come to light since the FDA lifted the recommended pause, including a report of problems following vaccination in a 55-year-old male.

Prasad <a href="https://www.documentcloud.org/documents/26073627-fda-ixchiq-suspension-memorandum/">said</a> in a memorandum dated Aug. 22 that of the 32 cases, five tested positive for the vaccine strain of the virus, making it nearly certain that the vaccine caused the problem.

“There are reasonable grounds to believe the risks of the vaccine outweigh its benefits, and that it poses a danger to health,” Prasad said. “Therefore, CBER is suspending approval.”

Chikungunya causes symptoms in most people who are infected with the virus, according to the CDC. Symptoms can include fever, joint pain, and inflammation.

Another vaccine against chikungunya, Vimkunya, is still available in the United States. The FDA approved it in April for people 12 years of age and older, and the CDC recommends it for people traveling to areas with chikungunya outbreaks and for laboratory workers who could become exposed to the virus in their work.

Vimkunya uses a molecule resembling the chikungunya virus to trigger an immune response. Ixchiq contains a weakened form of the virus.

Share prices of Valneva dipped by about 21 percent after the FDA’s suspension.

Valneva described the move as sudden. The company said that the SAEs recorded following vaccination featured symptoms consistent with those reported during clinical trials and that the labels accurately list warnings and precautions.

The label warns that Ixchiq could cause “serious, severe, or prolonged chikungunya-like illness,” citing trial data and reports following approval.

“Valneva is continuing to investigate these cases in detail and if warranted will pursue further steps in connection with FDA’s decision in accordance with applicable statutory procedures,” it stated.

<em>From <a href="https://www.theepochtimes.com/us/fda-suspends-license-for-chikungunya-vaccine-5905657">The Epoch Times</a></em>

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