Owens, who is black, is the communications director for Turning Point USA, a conservative group.
An Antifa-affiliated Twitter account told followers to call the university's president and other officials and urge them to cancel the talk.
"Their adulation of free speech and patriotism just barely veil a neo-fascist organization working hand-in-hand with a 'soft white power' movement to recruit 18- to 22-year-olds—a well-worn tactic of early fascists from the Blackshirts to the Hitler Youth," the user wrote in a series of tweets shared by Antifa's Philadelphia chapter.
The user added: "While less aggressive tactics continue, such as phone calls, emails, speaking with the staff, and spreading awareness on social media, it seems likely that a large-scale confrontation is inevitable. We consider TPUSA to be a threat to our city."
Other users issued threats, including one that said people should buy coyote urine at Walmart, put it in balloons, and throw them at Owens.
Owens posted footage of when she arrived on campus on Monday for the speech. Protesters shouted various phrases at her, including "[expletive] Candace Owens" and "[expletive] the police." Most of the protesters appeared to be white.
“We all know what she’s been doing around here. A lot of mocking, a lot of racist statements, saying racism doesn’t exist, mocking sexual assault victims,” Zhou said. “UMC was in full support of [the protest].”
Once inside the venue, Owens approached protesters to ask what she had said that they were offended by, according to protester Kate Silva, a freshman.
“She was coming over and looking at a lot of the posters and then asking students who were holding posters to give her examples of when she had said things or done things,” Silva said.
During her speech, Owens questioned the belief that all women who accuse men of sexual assault should be automatically trusted, linking the belief to racist beliefs in the past.
“The concept that we should just believe women is exactly what got my ancestors lynched,” Owens said. “We’ve learned our lesson the hard way with that.”
“We’ve given our vote for the last 60 years to the Democrat Party and we have absolutely nothing to show in return,” Owens said. “Why the hell did Hillary Clinton get 89% of the black vote when it was her husband, while she was with him in the Oval Office, that locked up more black men than any president in the history of the United States with his Three Strikes act?”