The site will also include new functionality, allowing consumers to compare brand-name and generic prices, as well as get home delivery on medications through partnerships with mail-order pharmacies.
With these additions, TrumpRx will feature the best and lowest prices on prescriptions used by tens of millions of Americans, Trump said.
Generic drugs are often much less expensive than their brand-name counterparts.
“In some cases the discounted generics … may be offered at an even lower cash price than the out-of-pocket insurance cost,” the president said.
The site has drawn 10 million users over the past three months, saving consumers more than $400 million, Trump said.
The Council of Economic Advisers estimates that these most-favorite-nation drug policies will save Americans nearly $600 billion over 10 years.
Executives from discount drug retailers, including Mark Cuban, founder of Mark Cuban Cost Plus Drug Company; Tanvi Patel, vice president of Amazon Pharmacy; and Aaron Crittenden, president of RX Marketplace at Good Rx, joined Trump for the announcement.
Expanded functionality on the site allows consumers to compare the cost of brand-name and generic drugs, find nearby pharmacies offering the medication, or click through to discount retailers to purchase drugs for home delivery.
“TrumpRx has created transparency with no middlemen,” Dr. Mehmet Oz, administrator of the Centers for Medicare and Medicaid services, said.
The businesses represented by Cuban, Tanvi, and Crittenden have similar models.
“As our volumes go up, our costs go down, which means we’ll be ending up charging less to people over a period of time,” Cuban said.
Cuban’s company supplies more than 1,000 frequently prescribed and high-cost generic medications at cost plus 15 percent. Forbes estimated that Cuban’s company had $25 million in sales in the first nine months after it started in 2023.
“It’s been our mission to build a pharmacy with price transparency,” Patel said of Amazon Pharmacy.
The site informs consumers of the cost of medications up front, regardless of whether they are paying by cash or insurance.
Amazon Pharmacy generated about $2 billion in revenue in 2024, according to pharmacy analysts Drug Channels.
“Almost one in three Americans, when they go to a drugstore, cannot afford to pick up the medications their doctor prescribed for them,” Oz said.
Nearly two-thirds—64 percent—of U.S. adults worry about affording health care, and 30 percent are very worried, according to an April 19 poll conducted by health care research group KFF.
About nine in 10 voters say health care affordability will influence their voting in the 2026 elections.
Chris Klomp, director of Medicare, said the lowered drug prices showed momentum on health care affordability.
“We are on an irreversible trajectory,” Klomp said, noting that users of GLP-1 medications will pay about $1,800 less for the course of treatment compared with four months ago.
Klomp also said that through TrumpRx, “an American family trying to conceive and needing fertility medications will save nearly $6,000 per live birth.”