The scientific statement, titled "Caffeine and Cardiovascular Disease," was published in the AHA's peer-reviewed journal "Circulation" and examined the latest research on how caffeine—the world's most widely consumed stimulant—interacts with the cardiovascular system.
Consuming up to 400 milligrams of caffeine per day, roughly the amount in five 8-ounce cups of black caffeinated coffee, is considered safe for most people and is linked to a reduced risk of heart failure, coronary heart disease, and stroke in some individuals. A standard cup of brewed, non-specialty coffee contains between 9.4 and 20.6 milligrams of caffeine per fluid ounce.
But Marcus warned that not all caffeine sources carry the same profile.
Why Energy Drinks Raise Concern
Energy shots can contain 40 to 69 milligrams of caffeine per fluid ounce—three to four times more than regular brewed coffee, according to the statement. That concentrated dosing has been associated with higher blood pressure and abnormal heart rhythms, particularly in adults younger than 30 who are otherwise considered low-risk for cardiovascular disease.Mixed Effects Depending on the Condition
The statement outlined varying effects across specific cardiovascular measures, according to the AHA:- Blood pressure: drinking one to three cups daily was tied to a higher risk of developing high blood pressure in people with otherwise normal readings, while drinking more than three cups was associated with a lower risk. Energy drinks, by contrast, can sharply raise blood pressure, especially in people who already have hypertension.
- Type 2 diabetes: regular consumption of black, unsweetened coffee was linked to lower diabetes risk, although researchers say compounds in coffee other than caffeine itself may be responsible.
- Cholesterol: cafestol, a compound found in unfiltered coffee such as French press, espresso, or Turkish coffee, was linked to higher LDL, or "bad," cholesterol. Paper-filtered and instant coffee do not contain cafestol.
- Heart rhythm: observational studies and related meta-analyses found that coffee consumption—particularly in regular and moderate amounts, i.e., 1-7 times a week and 1-3 cups of caffeinated coffee per day—was linked to a lower risk of atrial fibrillation but a higher frequency of premature ventricular contractions.
- Heart disease and stroke: two to four cups per day were associated with lower risk of heart disease, heart failure, and stroke, though more than four cups daily may raise heart failure risk.
Additives Could Undercut Benefits
The AHA noted that adding large amounts of sugar, flavored syrups, milk, or cream to coffee likely diminishes its potential cardiovascular benefits, though researchers say more study is needed to confirm the extent of that effect.Individual Variation Emphasized
Marcus cautioned against a one-size-fits-all approach to caffeine intake, noting that genetics, age, medications, and underlying health conditions all influence how a person's body processes caffeine.More Research Sought
The authors said that data are limited on tea, soda, energy drinks, and caffeine supplements compared with coffee, although tea has shown associations with reduced risk of atrial fibrillation, heart failure, and stroke similar to coffee's. Due to the lack of sufficient, rigorous data, caffeine was not included in the AHA's 2026 Dietary Guidance to Improve Cardiovascular Health.The statement was prepared on behalf of the AHA's Council on Lifestyle and Cardiometabolic Health, the Council on Clinical Cardiology, and the Stroke Council.
